Objectives of the department: i. To decipher the correlation between vasculogenic mimicry, angiogenesis and tumour invasiveness in the light of molecular signaling in different cancers. ii. To examine the role of Ephrin pathway in vasculogenic mimicry in breast and oral cancer progression. iii. To determine the molecular mechanism of cancer therapeutic and chemopreventive agents in signaling pathways, mRNA transcription and post transcription. iv. Establishment of RNA binding proteins as therapeutic agents against cancer. v. To assess the status of p16 and underpin its possible signal transduction pathway in oral premalignant lesions (leukoplakia, erythroplakia, Lichen planus and oral submucous fibrosis) associated with oral squamous cell carcinoma. vi.To study the effect of heavy metals, pesticides and tobacco on male fertility & testicular carcinoma in situ and chemopreventive agents targeting the therapeutic machinery of precancerous cellular condition.