Objective 1: To study the modulation of tumor markers by dietary phytochemicals sensitize cancer cells towards chemotherapeutic drugs Objective 2: To elucidate the effect of green tea polyphenol, EGCG on Lipid Rafts and Caveolae in human breast cancer cells MCF-7 and MDA-MB-231cells. Objective 3: Enhancement of imatinib sensitivity in drug resistant chronic myeloid leukemia cells K562 by curcumin via modulation of various signaling mechanism. Objective 4: Prevention of 4NQO induced oral cell carcinoma in animal model by black tea by modulation of different protein tyrosine kinases and their phosphorylation status. Objective 5: Determination of the constitutive expression of Aurora kinases A and B (AUR A and AUR B) in breast adenocarcinoma cell line MCF-7, highly metastatic breast cancer cell line MDA-MB-231 (triple negative). To follow the modulation of the same by curcumin. Objective 6: Synchronization of estrus cycle and determination of exfoliated cell morphology in female Swiss albino mice. Objective 7: Development of arsenic induced skin squamous cell carcinoma in Swiss albino mice and its prevention by black tea. Objective 8: Comparative study of population chronically exposed to arsenic in two different demographic regions of Eastern India: Identification of responsible genes and susceptible population